Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.

doi:10.1038/309592a0

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Article

Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.

Nature - 1 Jan 2000

Rabbitts T H, Forster A, Hamlyn P, Baer R

Abstract excerpt

Our previous studies of a translocated c-myc gene in the Raji Burkitt's lymphoma cell showed somatic mutations in exons 1 and 2. We have extended these observations to two other translocated c-myc genes and find a common occurrence of mutation in the noncoding exon 1. We also found that in Raji c...

Topics

Base Sequence
Burkitt Lymphoma
Cell Line
DNA
Humans
Mutation
Oncogenes
Transcription, Genetic
Translocation, Genetic

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