Article
Selective expression of one c-myc allele in two human myeloma cell lines.
Cancer research - 1 Oct 1996
Kuehl W M, Brents L A, Chesi M, Bergsagel P L
Abstract excerpt
Chromosomal translocations or DNA rearrangements affecting c-myc occur in almost all murine plasmacytoma and human Burkitt's lymphoma tumors and are associated with a high incidence of exon 2 missense mutations and selective expression of the affected allele. Screening nine multiple myeloma cell...
Topics
- Alleles
- B-Lymphocytes
- Burkitt Lymphoma
- Cell Line, Transformed
- DNA Mutational Analysis
- DNA, Neoplasm
- Exons
- Gene Expression Regulation, Neoplastic
- Genes, myc
- Herpesvirus 4, Human
- Humans
- Multiple Myeloma
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Tumor Cells, Cultured