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Article

Insertion of c- Myc into Igh Induces B-Cell and Plasma-Cell Neoplasms in Mice

15 Feb 2005

Abstract excerpt

We used gene targeting in mice to insert a His(6)-tagged mouse c-Myc cDNA, Myc(His), head to head into the mouse immunoglobulin heavy-chain locus, Igh, just 5' of the intronic enhancer, Emu. The insertion of Myc(His) mimicked both the human t(8;14)(q24;q32) translocation that results in the activation of MYC in human endemic Burkitt lymphomas and the homologous mouse T(12;15) translocation that deregulates Myc in...

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Identifiers

PMID: 15735016
DOI: 10.1158/0008-5472.can-04-0268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Insertion of c- Myc into Igh Induces B-Cell and Plasma-Cell Neoplasms in MicePMID 15735016Read ↗

Insertion of Myc into Igh accelerates peritoneal plasmacytomas in mice.Semantic proximity Read ↗

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