Article
Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas.
Nature genetics - 1 Sept 1993
Bhatia K, Huppi K, Spangler G, Siwarski D, Iyer R, Magrath I
Abstract excerpt
We have screened the entire coding region of c-myc in a panel of Burkitt's lymphomas (BLs) and mouse plasmacytomas (PCTs). Contrary to the belief that c-myc is wild type in these tumours, we found that 65% of 57 BLs and 30% of 10 PCTs tested exhibit at least one amino acid (aa) substitution. Thes...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Apoptosis
- Base Sequence
- Burkitt Lymphoma
- DNA Mutational Analysis
- DNA, Neoplasm
- Gene Expression Regulation, Neoplastic
- Genes, Dominant
- Genes, Immunoglobulin
- Genes, myc
- Humans
- Mice
- Molecular Sequence Data
- Phosphorylation
- Plasmacytoma
- Point Mutation