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Article

c-myc hypermutation in Burkitt's lymphoma.

Leukemia & lymphoma - 1 Dec 1992

Johnston J M, Carroll W L

Abstract excerpt

Translocation between the c-myc protooncogene and one of the three immunoglobulin loci is a cytogenetic hallmark of the B cell tumor, Burkitt's lymphoma. The resulting deregulation of c-myc expression is a critical step in tumorigenesis. The translocation breakpoint may lie within c-myc proper, in which case deregulation is due, in part, to dissociation of key 5' regulatory sequences from the protein-coding...

Topics

B-Lymphocytes
Burkitt Lymphoma
Gene Expression Regulation, Neoplastic
Genes, Immunoglobulin
Genes, myc
Humans
Mutation
Transcription, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1297477
DOI: 10.3109/10428199209051025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1297477-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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c-myc hypermutation in Burkitt's lymphoma.PMID 1297477Read ↗

Molecular Biology of Burkitt’s LymphomaSemantic proximity Read ↗

Mutations in the coding region of c-myc occur independently of mutations in the regulatory regions and are predominantly associated with myc/Ig translocation.Semantic proximity Read ↗

A Myc-associated zinc finger protein-related factor binding site is required for the deregulation of c-myc expression by the immunoglobulin heavy chain gene enhancers in Burkitt's lymphoma.Semantic proximity Read ↗

The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line.Semantic proximity Read ↗

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Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.Semantic proximity Read ↗

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