c-myc hypermutation is ongoing in endemic, but not all Burkitt's lymphoma.

Article

c-myc hypermutation is ongoing in endemic, but not all Burkitt's lymphoma.

Blood - 1 Nov 1991

Johnston J M, Yu M T, Carroll W L

Abstract excerpt

Deregulation of c-myc oncogene secondary to chromosomal translocation appears to play an essential role in the genesis of both endemic (African) Burkitt's lymphoma (eBL) and sporadic Burkitt's lymphoma (sBL). In most eBL, mutations in or near exon 1 disrupt normal c-myc regulatory sites. We exami...

Topics

Africa
Base Sequence
Blotting, Southern
Burkitt Lymphoma
Child, Preschool
Cloning, Molecular
DNA
Exons
Genes, myc
Humans
Male
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Regulatory Sequences, Nucleic Acid

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