Article
Nucleotide sequence comparison of normal and translocated murine c-myc genes.
Nature - 1 Jan 2000
Stanton L W, Fahrlander P D, Tesser P M, Marcu K B
Abstract excerpt
Plasmacytoid tumours in mice and Burkitt's lymphomas in humans display characteristic chromosomal translocations involving the c-myc proto-oncogene. Models to explain quantitative changes in c-myc expression have been proposed based on the loss of normal promoters as a result of translocation. However, alternative explanations, such as somatic mutation are needed to explain altered c-myc expression in the absence...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Gene Expression Regulation
- Genes
- Mice
- Mutation
- Oncogenes
- Plasmacytoma
- Proto-Oncogene Mas
- Spleen
- Translocation, Genetic
