Dysregulation of c-myc in multiple myeloma.

doi:10.1007/978-3-642-60801-8_29

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Article

Dysregulation of c-myc in multiple myeloma.

Current topics in microbiology and immunology - 1 Jan 1997

Kuehl W M, Brents L A, Chesi M, Huppi K, Bergsagel P L

Abstract excerpt

Translocation of c-myc to IgH switch regions, or less frequently to one of the IgL loci, is essentially an invariant event in murine plasmacytomas. This results in dysregulation of c-myc, manifested by selective expression of the translocated allele. Human multiple myeloma (MM) has a similarly high incidence of translocations involving IgH switch regions, but c-myc is infrequently involved as a partner in these...

Topics

Alleles
Animals
DNA, Neoplasm
Gene Expression
Gene Expression Regulation, Neoplastic
Genes, Immunoglobulin
Genes, myc
Humans
Immunoglobulin Heavy Chains
Mice
Multiple Myeloma
Polymerase Chain Reaction
Translocation, Genetic
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9308252
DOI: 10.1007/978-3-642-60801-8_29

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