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Article

Dysregulation of c-myc in multiple myeloma.

Current topics in microbiology and immunology - 1 Jan 1997

Kuehl W M, Brents L A, Chesi M, Huppi K, Bergsagel P L

Abstract excerpt

Translocation of c-myc to IgH switch regions, or less frequently to one of the IgL loci, is essentially an invariant event in murine plasmacytomas. This results in dysregulation of c-myc, manifested by selective expression of the translocated allele. Human multiple myeloma (MM) has a similarly high incidence of translocations involving IgH switch regions, but c-myc is infrequently involved as a partner in these...

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PMID: 9308252
DOI: 10.1007/978-3-642-60801-8_29

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Dysregulation of c-myc in multiple myeloma.PMID 9308252Read ↗

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Frequent Dysregulation of the c-maf Proto-Oncogene at 16q23 by Translocation to an Ig Locus in Multiple MyelomaSemantic proximity Read ↗

Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumorsSemantic proximity Read ↗

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The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line.Semantic proximity Read ↗

Immunoglobulin gene rearrangements and the pathogenesis of multiple myelomaSemantic proximity Read ↗

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