Polygenic control of susceptibility to murine systemic lupus erythematosus.

doi:10.1016/1074-7613(94)90100-7

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Article

Polygenic control of susceptibility to murine systemic lupus erythematosus.

Immunity - 1 Jun 1994

Morel L, Rudofsky U H, Longmate J A, Schiffenbauer J, Wakeland E K

Abstract excerpt

Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susce...

Topics

Animals
Antibodies, Antinuclear
Base Sequence
Chromosome Mapping
Crosses, Genetic
DNA Primers
Female
Genetic Linkage
Genetic Markers
H-2 Antigens
Heterozygote
Humans
Lupus Erythematosus, Systemic
Lupus Nephritis
Male
Mice
Mice, Inbred C57BL
Mice, Inbred Strains

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