Article
Multiplex inheritance of component phenotypes in a murine model of lupus.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 1999
Morel L, Mohan C, Yu Y, Schiffenbauer J, Rudofsky U H, Tian N, Longmate J A, Wakeland E K
Abstract excerpt
We analyzed the linkage of GN and a wide spectrum of serological phenotypes associated with systemic lupus erythematosus in a (NZM2410 x C57BL/6)F2 cross. Some phenotypes, such as glomerulonephritis (GN) and anti-chromatin IgG antibody production, were more penetrant in females, but others, such...
Topics
- Animals
- Antibodies
- Chromatin
- Chromosome Mapping
- Chromosomes
- DNA
- DNA, Single-Stranded
- Disease Models, Animal
- Disease Susceptibility
- Female
- Genes
- Glomerulonephritis
- Histones
- Immunoglobulin G
- Immunoglobulin M
- Lupus Erythematosus, Systemic
- Male
- Mice