Article
Multiplex inheritance of component phenotypes in a murine model of lupus.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 1999
Morel L, Mohan C, Yu Y, Schiffenbauer J, Rudofsky U H, Tian N, Longmate J A, Wakeland E K
Abstract excerpt
We analyzed the linkage of GN and a wide spectrum of serological phenotypes associated with systemic lupus erythematosus in a (NZM2410 x C57BL/6)F2 cross. Some phenotypes, such as glomerulonephritis (GN) and anti-chromatin IgG antibody production, were more penetrant in females, but others, such as anti-dsDNA antibody production, did not show a gender bias. These results suggest that gender bias affects only a...
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