Article
NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci.
Clinical immunology (Orlando, Fla.) - 1 Sept 2001
Waters S T, Fu S M, Gaskin F, Deshmukh U S, Sung S S, Kannapell C C, Tung K S, McEwen S B, McDuffie M
Abstract excerpt
Among NZB/W-derived New Zealand mixed (NZM) strains, only NZM/Aeg2410 (NZM2410) has been well characterized. In contrast to NZM2410, NZM2328 mice develop autoantibodies and acute and severe chronic glomerulonephritis (GN) with female predominance similarly to NZB/WF1 and humans with systemic lupus erythematosus (SLE). Chronic GN with glomerular sclerosis and tubular atrophy but not acute GN was correlated with...
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