Article
Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2001
Xie S, Chang S, Yang P, Jacob C, Kaliyaperumal A, Datta S K, Mohan C
Abstract excerpt
(SWR x New Zealand Black (NZB))F(1) (or SNF(1)) mice succumb to lupus nephritis. Although several NZB lupus susceptibility loci have been identified in other crosses, the potential genetic contributions of SWR to lupus remain unknown. To ascertain this, a panel of 86 NZB x F(1) backcross mice was immunophenotyped and genome scanned. Linkage analysis revealed four dominant SWR susceptibility loci (H2, Swrl-1,...
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