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Article

Mapping lupus susceptibility genes in the NZM2410 mouse model.

Advances in immunology - 1 Jan 2012

Morel Laurence

Abstract excerpt

Considerable efforts have been deployed over the years to decipher the genetic basis of systemic lupus erythematosus (SLE). The NZM2410 strain is murine model in which the genetic analysis of SLE is the most advanced. NZM2410 studies have shown that, as in SLE patients, lupus susceptibility is achieved by the coexpression of many susceptibility alleles, each of which with a small contribution to the overall...

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PMID: 22608257
DOI: 10.1016/B978-0-12-394299-9.00004-7

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