Article
Mutation of the conserved Gly94 and Gly126 in elongation factor Tu from Escherichia coli. Elucidation of their structural and functional roles.
European journal of biochemistry - 15 Feb 1995
Knudsen C R, Kjaersgård I V, Wiborg O, Clark B F
Abstract excerpt
All guanine-nucleotide-binding proteins cycle between an inactive, GDP-bound and an active, GTP-bound conformation whereby they function as molecular switches. Elongation factor Tu from Escherichia coli is used as a model for defining residues important in the switch mechanism. Gly94 and Gly126 w...
Topics
- Base Sequence
- Escherichia coli
- GTP Phosphohydrolase-Linked Elongation Factors
- Guanosine Diphosphate
- Guanosine Triphosphate
- Molecular Sequence Data
- Mutation
- Peptide Elongation Factor Tu
- Protein Biosynthesis
- RNA, Transfer, Amino Acyl
- Structure-Activity Relationship