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Article

A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome.

Journal of bacteriology - 1 Jan 1993

Tubulekas I, Hughes D

Abstract excerpt

Elongation factor Tu (EF-Tu).GTP has the primary function of promoting the efficient and correct interaction of aminoacyl-tRNA with the ribosome. Very little is known about the elements in EF-Tu involved in this interaction. We describe a mutant form of EF-Tu, isolated in Salmonella typhimurium, that causes a severe defect in the interaction of the ternary complex with the ribosome. The mutation causes the...

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Identifiers

PMID: 8416899
DOI: 10.1128/jb.175.1.240-250.1993
PMCID: PMC196119

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