Article
A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome.
Journal of bacteriology - 1 Jan 1993
Tubulekas I, Hughes D
Abstract excerpt
Elongation factor Tu (EF-Tu).GTP has the primary function of promoting the efficient and correct interaction of aminoacyl-tRNA with the ribosome. Very little is known about the elements in EF-Tu involved in this interaction. We describe a mutant form of EF-Tu, isolated in Salmonella typhimurium,...
Topics
- Anti-Bacterial Agents
- Glycine
- Guanosine Triphosphate
- Hydrolysis
- Kinetics
- Macromolecular Substances
- Models, Molecular
- Peptide Elongation Factor Tu
- Phenotype
- Protein Biosynthesis
- Protein Conformation
- Pyridones
- RNA, Transfer, Amino Acyl
- RNA, Transfer, Phe
- Ribosomes
- Salmonella typhimurium
- Valine