Article
Serum-sensitive mutation of Francisella novicida: association with an ABC transporter gene.
Microbiology (Reading, England) - 1 Dec 1994
Mdluli K E, Anthony L S, Baron G S, McDonald M K, Myltseva S V, Nano F E
Abstract excerpt
Francisella novicida is a facultative intracellular pathogen that can survive and grow in macrophages by preventing phagolysosomal fusion. In this study in vitro cassette mutagenesis was used to generate a library of insertion mutants of F.novicida. Two related mutants, KM14 and KM14S, initially identified as defective for growth in macrophages, were found to be sensitive to serum. These mutants were also found...
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