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Article

Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis.

Infection and immunity - 1 Dec 2006

Brotcke Anna, Weiss David S, Kim Charles C, Chain Patrick, Malfatti Stephanie, Garcia Emilio, Monack Denise M

Abstract excerpt

The facultative intracellular bacterium Francisella tularensis causes the zoonotic disease tularemia. F. tularensis resides within host macrophages in vivo, and this ability is essential for pathogenesis. The transcription factor MglA is required for the expression of several Francisella genes that are necessary for replication in macrophages and for virulence in mice. We hypothesized that the identification of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17000729
DOI: 10.1128/IAI.01250-06
PMCID: PMC1698089

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Source receipt: pubmed, retrieved 7 Sept 2026.

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