A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia.

doi:10.1371/journal.pone.0174106

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A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia.

PloS one - 1 Jan 2017

Chance Taylor, Chua Jennifer, Toothman Ronald G, Ladner Jason T, Nuss Jonathan E, Raymond Jo Lynne, Biot Fabrice V, Demons Samandra, Miller Lynda, Halasohoris Stephanie, Mou Sherry, Koroleva Galina, Lovett Sean, Palacios Gustavo, Vietri Nicholas J, Worsham Patricia L, Cote Christopher K, Kijek Todd M, Bozue Joel A

Abstract excerpt

Francisella tularensis, a gram-negative facultative intracellular bacterial pathogen, is the causative agent of tularemia and able to infect many mammalian species, including humans. Because of its ability to cause a lethal infection, low infectious dose, and aerosolizable nature, F. tularensis subspecies tularensis is considered a potential biowarfare agent. Due to its in vitro efficacy, ciprofloxacin is one of...

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PMID: 28328947
DOI: 10.1371/journal.pone.0174106
PMCID: PMC5362203

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A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia.PMID 28328947Read ↗

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