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Article

In vivo Himar1-based transposon mutagenesis of Francisella tularensis.

Applied and environmental microbiology - 1 Mar 2006

Maier Tamara M, Pechous Roger, Casey Monika, Zahrt Thomas C, Frank D W

Abstract excerpt

Francisella tularensis is the intracellular pathogen that causes human tularemia. It is recognized as a potential agent of bioterrorism due to its low infectious dose and multiple routes of entry. We report the development of a Himar1-based random mutagenesis system for F. tularensis (HimarFT). In vivo mutagenesis of F. tularensis live vaccine strain (LVS) with HimarFT occurs at high efficiency. Approximately 12...

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Identifiers

PMID: 16517634
DOI: 10.1128/AEM.72.3.1878-1885.2006
PMCID: PMC1393221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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