Article
Mouse cells with null p53 mutation have all p53 isoforms deleted and lose negative growth control.
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society - 1 Jan 1994
Selkirk J K, He C, Merrick B A
Abstract excerpt
Embryonic mouse cells containing a disrupted p53 gene (-/-) were compared to the heterozygote (+/-) and homozygote control (+/+) for growth characteristics and the presence of p53 protein isoforms. There were considerable morphological differences between the null cells and homozygote, with the n...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Division
- Cell Nucleus
- Cells, Cultured
- Cricetinae
- Cytoplasm
- Electrophoresis, Gel, Two-Dimensional
- Embryo, Mammalian
- Fibroblasts
- Genes, p53
- Immunosorbent Techniques