Article
Mouse cells with null p53 mutation have all p53 isoforms deleted and lose negative growth control.
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society - 1 Jan 1994
Selkirk J K, He C, Merrick B A
Abstract excerpt
Embryonic mouse cells containing a disrupted p53 gene (-/-) were compared to the heterozygote (+/-) and homozygote control (+/+) for growth characteristics and the presence of p53 protein isoforms. There were considerable morphological differences between the null cells and homozygote, with the null cells having irregular shapes and sizes, and densely staining pleomorphic nuclei. Growth curves showed the null...
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