Article
Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo.
Cell death and differentiation - 1 Jun 2006
Wahl G M
Abstract excerpt
P53 is a transcription factor that can cause cells to be eliminated by apoptosis or senescent-like arrest upon its activation by irreparable genetic damage, excessively expressed oncogenes, or a broad spectrum of other stresses. As P53 executes life and death decisions, its activity must be stringently regulated, which implies that it is not likely to be controlled by a simple regulatory mechanism involving a...
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