A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation.

doi:10.1038/nm0796-804

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Article

A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation.

Nature medicine - 1 Jul 1996

Lutzker S G, Levine A J

Abstract excerpt

Testicular teratocarcinomas never contain p53 gene mutations even though these tumors express high levels of nuclear p53 protein. We have characterized two murine teratocarcinoma cell lines and find no evidence that endogenous p53-regulated genes are correspondingly upregulated. Differentiation o...

Topics

Animals
Apoptosis
Cell Differentiation
DNA Damage
Male
Mice
Mice, Inbred BALB C
Mutation
Teratoma
Transcription, Genetic
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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