Article
Transcriptional activation by p53 correlates with suppression of growth but not transformation.
Cell - 2 Dec 1994
Crook T, Marston N J, Sara E A, Vousden K H
Abstract excerpt
The tumor suppressor protein p53 shows growth and transformation suppression functions that are frequently lost by mutant proteins detected in cancers. Using a large series of p53 mutants, we have demonstrated an excellent correlation between transcriptional activation and growth suppression in p...
Topics
- Animals
- Cell Division
- Cell Transformation, Neoplastic
- Fibroblasts
- Gene Expression Regulation
- Humans
- Mutation
- Neoplasms
- Osteosarcoma
- Rats
- Recombinant Proteins
- Transcription, Genetic
- Transcriptional Activation
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53