Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

Cell - 2 Dec 1994

Crook T, Marston N J, Sara E A, Vousden K H

Abstract excerpt

The tumor suppressor protein p53 shows growth and transformation suppression functions that are frequently lost by mutant proteins detected in cancers. Using a large series of p53 mutants, we have demonstrated an excellent correlation between transcriptional activation and growth suppression in p53-null human cells. Not all transcriptionally active mutants retain the ability to suppress transformation in primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Gene Expression Regulation
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Recombinant Proteins

Share to Transcription, Genetic

Share to Transfection

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8001119
DOI: 10.1016/0092-8674(94)90071-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional activation by p53 correlates with suppression of growth but not transformation.PMID 8001119Read ↗

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.Semantic proximity Read ↗

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages.Semantic proximity Read ↗

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.Semantic proximity Read ↗

Sequence-specific transcriptional activation is essential for growth suppression by p53.Semantic proximity Read ↗

The properties of p53 proteins selected for the loss of suppression of transformation.Semantic proximity Read ↗

The growth-inhibitory function of p53 is separable from transactivation, apoptosis and suppression of transformation by E1a and Ras.Semantic proximity Read ↗

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.Semantic proximity Read ↗

Oncogenic forms of p53 inhibit p53-regulated gene expressionSemantic proximity Read ↗

Oncogenic Forms of p53 Inhibit p53-Regulated Gene ExpressionSemantic proximity Read ↗

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.Semantic proximity Read ↗

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.Semantic proximity Read ↗

Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.