p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene.

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Article

p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene.

Cancer research - 1 Nov 1994

Weinberg W C, Azzoli C G, Kadiwar N, Yuspa S H

Abstract excerpt

Epidermal keratinocyte cultures were established from newborn mice expressing a null mutation in the p53 gene to explore the contribution of p53 to epidermal growth regulation and neoplasia. Keratinocytes were initiated by transduction with a replication-defective retrovirus encoding the v-rasHa...

Topics

Amino Acid Sequence
Animals
Animals, Newborn
Base Sequence
Calcium
Carcinoma
Cell Division
Cells, Cultured
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
ErbB Receptors
Gene Deletion
Genes, myc
Genes, p53
Genes, ras
Genotype
Keratinocytes
Mice

Source

Open in PubMed

Identifiers

PMID: 7923201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7923201-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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