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Article

p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene.

Cancer research - 1 Nov 1994

Weinberg W C, Azzoli C G, Kadiwar N, Yuspa S H

Abstract excerpt

Epidermal keratinocyte cultures were established from newborn mice expressing a null mutation in the p53 gene to explore the contribution of p53 to epidermal growth regulation and neoplasia. Keratinocytes were initiated by transduction with a replication-defective retrovirus encoding the v-rasHa oncogene and grafted onto nude mouse hosts. Tumors arising from keratinocytes heterozygous or null for functional p53...

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PMID: 7923201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene.PMID 7923201Read ↗

The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation.Semantic proximity Read ↗

Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands.Semantic proximity Read ↗

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Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma.Semantic proximity Read ↗

Distinct downstream targets manifest p53-dependent pathologies in mice.Semantic proximity Read ↗

Step-wise progression in human skin carcinogenesis in vitro involves mutational inactivation of p53, rasH oncogene activation and additional chromosome loss.Semantic proximity Read ↗

p53 protects against skin cancer induction by UV-B radiation.Semantic proximity Read ↗

Alterations of the p53 tumor suppressor gene during mouse skin tumor progression.Semantic proximity Read ↗

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.Semantic proximity Read ↗

A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.Semantic proximity Read ↗

Defects in transforming growth factor-β signaling cooperate with a <i>Ras</i> oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytesSemantic proximity Read ↗

Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.Semantic proximity Read ↗

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