Article
Inhibition of the mutant p53 gene in transformation assays.
The Journal of surgical research - 1 Apr 1992
Beenken S W, Raycroft L, Lozano G
Abstract excerpt
Mutation of the p53 gene is a key element in the development of several human cancers. Intron 4, a noncoding region of the p53 gene, is required for optimal expression of that gene. We have previously shown that nuclear protein binds intron 4 and have defined the protein-binding site. In this paper we address the question, "Does the mutant p53 gene's ability to transform cells to the malignant phenotype depend on...
Topics
- Animals
- Base Composition
- Binding Sites
- Cell Transformation, Neoplastic
- Fibroblasts
- Genes
- Introns
- Molecular Sequence Data
- Mutation
- Phenotype
- Proteins
- Rats