Article
p53 loss of function: implications for the processes of immortalization and tumorigenesis.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Aug 1992
Finlay C A
Abstract excerpt
The complex process of cell immortalization and transformation is likely to involve the inactivation of growth regulatory genes. Mutations (deletions, missense mutations) in the p53 gene are the most frequently observed genetic alteration in human tumors, making p53 a candidate for a cellular pro...
Topics
- Animals
- Cell Death
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Chick Embryo
- Fibroblasts
- Genetic Predisposition to Disease
- Humans
- Mice
- Mice, Knockout
- Neoplasms
- Neoplasms, Experimental
- Tumor Suppressor Protein p53