Article
p53 pathway is involved in cell competition during mouse embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jan 2017
Zhang Guoxin, Xie Yinyin, Zhou Ying, Xiang Cong, Chen Lai, Zhang Chenxi, Hou Xiaoshuang, Chen Jiong, Zong Hui, Liu Geng
Abstract excerpt
The function of tumor suppressor p53 has been under intense investigation. Acute stresses such as DNA damage are able to trigger a high level of p53 activity, leading to cell cycle arrest or apoptosis. In contrast, the cellular response of mild p53 activity induced by low-level stress in vivo remains largely unexplored. Murine double minute (MDM)2 and MDM4 are two major negative regulators of p53. Here, we used...
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