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Article

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

Genes & development - 1 Dec 1991

Harvey D M, Levine A J

Abstract excerpt

It has been shown previously that mutant p53 can act as an immortalizing gene when cotransfected into primary rat embryo fibroblasts along with a selectable marker. To determine whether a mutation at the p53 locus is a common event in the pathways leading to spontaneous cellular immortalization, 11 clonally derived BALB/c murine embryo fibroblast lines were established by passage on a 3T3 schedule and examined...

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Identifiers

PMID: 1752433
DOI: 10.1101/gad.5.12b.2375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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