Article
Altered protein synthesis in p53 null and hemizygous transgenic mouse embryonic fibroblasts.
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society - 1 Jan 1995
He C, Merrick B A, Patterson R M, Selkirk J K
Abstract excerpt
Embryonic fibroblasts derived from p53-deficient transgenic mice showed distinct phenotypic and biological changes in vitro. In this study, we investigated the possible impact of p53 on the synthesis of other cellular proteins by comparing the protein profiles of p53 null (-/-), hemizygous (+/-) and p53 positive homozygous (+/+) cells using high resolution two dimensional gel electrophoresis. A total of more than...
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