Article
p53 influences mice skeletal development.
Journal of craniofacial genetics and developmental biology - 1 Jan 2000
Ohyama K, Chung C H, Chen E, Gibson C W, Misof K, Fratzl P, Shapiro I M
Abstract excerpt
The p53 tumor suppressor gene encodes a transcriptional activator whose targets include genes that regulate cell cycle progression and apoptosis. Since we have shown that a critical event in the life history of the chondrocyte is programmed cell death, we asked the question: does loss of the p53...
Topics
- Animals
- Apoptosis
- Bone Diseases, Developmental
- Calcification, Physiologic
- Craniofacial Abnormalities
- Fetus
- Genes, p53
- Genotype
- Growth Plate
- Heterozygote
- Homozygote
- Mice
- Mice, Knockout
- Microscopy, Electron, Scanning
- Phenotype