Article
p53 influences mice skeletal development.
Journal of craniofacial genetics and developmental biology - 1 Jan 2000
Ohyama K, Chung C H, Chen E, Gibson C W, Misof K, Fratzl P, Shapiro I M
Abstract excerpt
The p53 tumor suppressor gene encodes a transcriptional activator whose targets include genes that regulate cell cycle progression and apoptosis. Since we have shown that a critical event in the life history of the chondrocyte is programmed cell death, we asked the question: does loss of the p53 gene influence skeletogenesis? Female p53(+/-) mice were mated with p53(+/-) male mice and 17-day-old fetal mice were...
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