Article
The importance of a single G in the hairpin loop of the iron responsive element (IRE) in ferritin mRNA for structure: an NMR spectroscopy study.
Nucleic acids research - 11 Jan 1995
Sierzputowska-Gracz H, McKenzie R A, Theil E C
Abstract excerpt
Noncoding sequences regulate the function of mRNA and DNA. In animal mRNAs, iron responsive elements (IREs) regulate the synthesis of proteins for iron storage, uptake and red cell heme formation. Folding of the IRE was indicated previously by reactivity with chemical and enzymatic probes. 1H- and 31P-NMR spectra now confirm the IRE folding; an atypical 31P-spectrum, differential accessibility of imino protons to...
Topics
- Animals
- Base Sequence
- Ferritins
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Molecular Sequence Data
- Molecular Structure
- Mutation
- Nucleic Acid Conformation
- Protons
- RNA, Messenger