Article
Temperature-controlled structural alterations of an RNA thermometer.
The Journal of biological chemistry - 28 Nov 2003
Chowdhury Saheli, Ragaz Curdin, Kreuger Emma, Narberhaus Franz
Abstract excerpt
Thermoresponsive structures in the 5'-untranslated region of mRNA are known to control translation of heat shock and virulence genes. Expression of many rhizobial heat shock genes is regulated by a conserved sequence element called ROSE for repression of heat shock gene expression. This cis-acting, untranslated mRNA is thought to prevent ribosome access at low temperature through an extended secondary structure,...
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