Article
Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression.
RNA (New York, N.Y.) - 1 Jan 2002
Zanier Katia, Luyten Ingrid, Crombie Catriona, Muller Berndt, Schümperli Daniel, Linge Jens P, Nilges Michael, Sattler Michael
Abstract excerpt
Expression of replication-dependent histone genes requires a conserved hairpin RNA element in the 3' untranslated regions of poly(A)-less histone mRNAs. The 3' hairpin element is recognized by the hairpin-binding protein or stem-loop-binding protein (HBP/SLBP). This protein-RNA interaction is important for the endonucleolytic cleavage generating the mature mRNA 3' end. The 3' hairpin and presumably HBP/SLBP are...
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