Article

Human Ribosomal G-Quadruplexes Regulate Heme Bioavailability

2020-04-15

Abstract excerpt

<h4>ABSTRACT</h4> The in vitro formation of stable G-quadruplexes (G4s) in human ribosomal RNA (rRNA) was recently reported. However, their formation in cells and their cellular roles have not been resolved. Here, by taking a chemical biology approach that integrates results from immunofluorescence, G4 ligands, heme affinity reagents, and a genetically encoded fluorescent heme sensor, we report that human riboso...

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Literature Corpus work: dc045f8c-7937-57a6-a915-63b6a9256c54
DOI: 10.1101/2020.04.15.042721

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