Article
The secondary structure of the regulatory region of the transferrin receptor mRNA deduced by enzymatic cleavage.
The New biologist - 1 Apr 1992
Horowitz J A, Harford J B
Abstract excerpt
The secondary structure of the portion of the transferrin receptor mRNA responsible for the regulation of the transcript's half-life has been deduced by ribonuclease H cleavage directed by antisense oligodeoxyribonucleotides as well as with other ribonucleases sensitive to RNA secondary structure. The data indicate that both a synthetic 252-nucleotide RNA and the comparable portion of a 2.7-kb cellular mRNA...
Topics
- Animals
- Base Sequence
- Genes, Regulator
- Humans
- Iron
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA, Messenger
- Receptors, Transferrin
- Ribonuclease H
- Transcription, Genetic