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NMR Studies of the Structure and Function of the HIV-1 5′-Leader

21 Dec 2016

Abstract excerpt

The 5'-leader of the human immunodeficiency virus type 1 (HIV-1) genome plays several critical roles during viral replication, including differentially establishing mRNA versus genomic RNA (gRNA) fates. As observed for proteins, the function of the RNA is tightly regulated by its structure, and a common paradigm has been that genome function is temporally modulated by structural changes in the 5'-leader. Over the...

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PMID: 28009832
DOI: 10.3390/v8120338

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