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Article

Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in Dictyostelium.

The Journal of biological chemistry - 25 Jan 2013

Choi Chang-Hoon, Thomason Peter A, Zaki Mehreen, Insall Robert H, Barber Diane L

Abstract excerpt

Phosphorylation of the actin-related protein 2 (Arp2) subunit of the Arp2/3 complex on evolutionarily conserved threonine and tyrosine residues was recently identified and shown to be necessary for nucleating activity of the Arp2/3 complex and membrane protrusion of Drosophila cells. Here we use the Dictyostelium diploid system to replace the essential Arp2 protein with mutants that cannot be phosphorylated at...

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Identifiers

PMID: 23223240
DOI: 10.1074/jbc.M112.435313
PMCID: PMC3554915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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