Induction of DNA double-strand breaks by restriction enzymes in X-ray-sensitive mutant Chinese hamster ovary cells measured by pulsed-field gel electrophoresis.

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Article

Induction of DNA double-strand breaks by restriction enzymes in X-ray-sensitive mutant Chinese hamster ovary cells measured by pulsed-field gel electrophoresis.

Radiation research - 1 Feb 1995

Kinashi Y, Okayasu R, Iliakis G E, Nagasawa H, Little J B

Abstract excerpt

This investigation was designed to determine whether the cytotoxic effects of different restriction endonucleases are related to the number and type of DNA double-strand breaks (DSBs) they produce. Chinese hamster ovary (CHO) K1 and xrs-5 cells, a radiosensitive mutant of CHO K1, were exposed to...

Topics

Animals
CHO Cells
Cell Survival
Cricetinae
Cricetulus
DNA
DNA Damage
DNA Restriction Enzymes
Electrophoresis, Gel, Pulsed-Field
Hydrolysis
Mutation
Radiation Tolerance
X-Rays

Source

Open in PubMed

Identifiers

PMID: 7838953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7838953-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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