Article
Evidence that DNA double-strand breaks initiate the phenotype of delayed reproductive death in Chinese hamster ovary cells.
Radiation research - 1 Jul 1992
Chang W P, Little J B
Abstract excerpt
A persistently reduced cloning efficiency occurs in many of the cloned progeny of Chinese hamster ovary (CHO) cells surviving X irradiation, a stable phenotype we have previously termed delayed reproductive death (Int. J. Radiat. Biol. 60, 483-496, 1991). We now report that this phenotype is also induced by the alkylating agent ethyl methanesulfonate (EMS), but not by irradiation with ultraviolet light. The...
Topics
- Animals
- CHO Cells
- Cell Death
- Cricetinae
- DNA
- DNA Damage
- Ethyl Methanesulfonate
- Phenotype
- Time Factors