The induction and reversal of topoisomerase II cleavable complexes formed by nuclear extract from the CHO DNA repair mutant, xrs1.

doi:10.1016/0921-8777(93)90077-t

Back to search

Article

The induction and reversal of topoisomerase II cleavable complexes formed by nuclear extract from the CHO DNA repair mutant, xrs1.

Mutation research - 1 Mar 1993

Caldecott K, Banks G, Jeggo P

Abstract excerpt

The gamma-ray sensitive CHO cell mutant xrs1 is hypersensitive to antitumour drugs that stabilise DNA topoisomerase II (topoII) cleavable complexes. Sensitivity appears to result from DNA double-strand breaks (DSBs) that persist in xrs1 cells, but not wild-type CHO-K1 cells, following drug remova...

Topics

Animals
CHO Cells
Cricetinae
Cricetulus
DNA
DNA Repair
DNA Topoisomerases, Type II
Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.