Reparable and non-reparable DNA strand breaks induced by X-irradiation in CHO K1 cells and the radiosensitive mutants xrs1 and xrs5.

doi:10.1080/09553009314551071

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Article

Reparable and non-reparable DNA strand breaks induced by X-irradiation in CHO K1 cells and the radiosensitive mutants xrs1 and xrs5.

International journal of radiation biology - 1 Jul 1993

Dahm-Daphi J, Dikomey E, Pyttlik C, Jeggo P A

Abstract excerpt

Repair kinetics of X-ray-induced DNA lesions was measured for CHO K1, xrs1 and xrs5 cells using the alkaline unwinding technique. Cells were irradiated on ice with X-ray doses of 9, 30 and 90 Gy followed by repair incubation at 37 degrees C. Repair was studied for up to 60 h to cover the kinetics...

Topics

Animals
CHO Cells
Cricetinae
DNA
DNA Damage
DNA Repair
Mutation
Radiation Tolerance

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