Article
Reparable and non-reparable DNA strand breaks induced by X-irradiation in CHO K1 cells and the radiosensitive mutants xrs1 and xrs5.
International journal of radiation biology - 1 Jul 1993
Dahm-Daphi J, Dikomey E, Pyttlik C, Jeggo P A
Abstract excerpt
Repair kinetics of X-ray-induced DNA lesions was measured for CHO K1, xrs1 and xrs5 cells using the alkaline unwinding technique. Cells were irradiated on ice with X-ray doses of 9, 30 and 90 Gy followed by repair incubation at 37 degrees C. Repair was studied for up to 60 h to cover the kinetics of reparable and non-reparable DNA damage. The kinetics of single-strand break (ssb) repair was found to be the same...
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