Article
Biochemical evidence for two different mechanisms for bleomycin-induced cell killing.
Mutation research - 1 Jun 1991
Giaccia A J, Shieh J, Cholon A, Brown J M
Abstract excerpt
Using pulsed-field gel electrophoresis, we have measured the ability of two bleomycin-sensitive mutants, XR-1 and BL-10, to repair DNA double-strands breaks (DSB). XR-1 was originally isolated by its hypersensitivity to killing with ionizing radiation, but we have also shown that it is sensitive...
Topics
- Animals
- Bleomycin
- Cell Line
- Cell Survival
- DNA Damage
- DNA Repair
- Electrophoresis, Agar Gel
- Kinetics
- Mutation