Article
Increased sensitivity to killing by restriction enzymes in the XR-1 DNA double-strand break repair-deficient mutant.
Mutation research - 1 Jul 1990
Giaccia A J, MacLaren R A, Denko N, Nicolaou D, Stamato T D
Abstract excerpt
Repair or misrepair of DNA double-strand breaks (DSBs) is critical in determining cellular survival after gamma-irradiation. In this report, we focus on the cellular and biochemical consequences of restriction enzyme induced DSBs in wild-type Chinese hamster ovary (CHO) cells and the DNA DSB repa...
Topics
- Animals
- Cell Line
- Cell Survival
- Chromosome Aberrations
- DNA Damage
- DNA Repair
- DNA Restriction Enzymes
- Deoxyribonuclease EcoRI
- Glucosephosphate Dehydrogenase
- Gonadotropins, Equine
- Mutation
- Plasmids