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Increased sensitivity to killing by restriction enzymes in the XR-1 DNA double-strand break repair-deficient mutant.

Mutation research - 1 Jul 1990

Giaccia A J, MacLaren R A, Denko N, Nicolaou D, Stamato T D

Abstract excerpt

Repair or misrepair of DNA double-strand breaks (DSBs) is critical in determining cellular survival after gamma-irradiation. In this report, we focus on the cellular and biochemical consequences of restriction enzyme induced DSBs in wild-type Chinese hamster ovary (CHO) cells and the DNA DSB repair-defective mutant XR-1. We find that XR-1 possesses reduced cellular survival after the introduction of restriction...

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Identifiers

PMID: 2164147
DOI: 10.1016/0921-8777(90)90034-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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