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Article

Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells.

International journal of radiation biology - 1 Jan 2003

Nagasawa H, Huo L, Little J B

Abstract excerpt

PURPOSE: We have shown previously that when monolayer cultures of Chinese hamster ovary (CHO) cells are exposed to very low fluences of alpha-particles, HPRT mutations are induced in non-irradiated 'bystander' cells in the population. The present investigation was designed to examine the role of DNA repair in this process. MATERIALS AND METHODS: The DNA double-strand repair-deficient mutant cell line xrs-5 was...

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PMID: 12556329

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