Article
X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining.
Mutation research - 1 Jan 2000
Kemp L M, Sedgwick S G, Jeggo P A
Abstract excerpt
Six CHO mutants have previously been described as being sensitive to ionizing radiation and bleomycin treatment, with little or no cross sensitivity to UV-radiation (Jeggo and Kemp, 1983). Their ability to rejoin single- and double-strand breaks has been examined here. Using two techniques, gradient sedimentation and alkaline elution, no difference could be observed between wild-type and mutant strains in the...
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