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Article

Posttranslational regulation of I-Ed by affinity for CLIP.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2007

Rinderknecht Cornelia H, Belmares Michael P, Catanzarite Tatiana L W, Bankovich Alexander J, Holmes Tyson H, Garcia K Christopher, Nanda Navreet K, Busch Robert, Kovats Susan, Mellins Elizabeth D

Abstract excerpt

Several MHC class II alleles linked with autoimmune diseases form unusually low stability complexes with CLIP, leading us to hypothesize that this is an important feature contributing to autoimmune pathogenesis. To investigate cellular consequences of altering class II/CLIP affinity, we evaluated invariant chain (Ii) mutants with varying CLIP affinity for a mouse class II allele, I-E(d), which has low affinity...

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Share to Antigen Presentation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17947664
DOI: 10.4049/jimmunol.179.9.5907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Posttranslational regulation of I-Ed by affinity for CLIP.PMID 17947664Read ↗

I-Ag7 is subject to post-translational chaperoning by CLIP.Semantic proximity Read ↗

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).Semantic proximity Read ↗

DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.Semantic proximity Read ↗

Revisiting nonclassical HLA II functions in antigen presentation: Peptide editing and its modulation.Semantic proximity Read ↗

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An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading.Semantic proximity Read ↗

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