Spontaneous mutations at aprt locus in a mammalian cell line defective in mismatch recognition.

doi:10.1007/BF02257458

Back to search

Article

Spontaneous mutations at aprt locus in a mammalian cell line defective in mismatch recognition.

Somatic cell and molecular genetics - 1 Sept 1994

Hess P, Aquilina G, Dogliotti E, Bignami M

Abstract excerpt

Clone B is a CHO cell line that shows a moderate mutator phenotype as a consequence of a defect in mismatch recognition. To identify the classes of mutation that accumulate spontaneously in a functional gene, we isolated and sequenced 54 clone B spontaneous mutants at the adenine phosphoribosyltr...

Topics

Adenine Phosphoribosyltransferase
Animals
Base Sequence
CHO Cells
Cricetinae
DNA
DNA Mutational Analysis
DNA Repair
DNA Replication
Frameshift Mutation
Molecular Sequence Data
Mutation
Nucleic Acid Heteroduplexes

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.