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Article

DNA sequence analysis of mutations induced by melphalan in the CHO aprt locus.

Cancer genetics and cytogenetics - 1 Nov 1992

Austin M J, Han Y H, Povirk L F

Abstract excerpt

In previous work, we established that treatment with melphalan (L-phenylalanine mustard) produced a predominance of A.T-->T.A transversions in the Simian virus 40 (SV40)-based shuttle vector pZ189 during replication in human 293 cells. Mutations were induced with varying doses (4-12 microM) melphalan in the aprt gene of the hemizygous Chinese hamster ovary (CHO) cell line D422 to determine whether a similar...

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Identifiers

PMID: 1458453
DOI: 10.1016/0165-4608(92)90326-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA sequence analysis of mutations induced by melphalan in the CHO aprt locus.PMID 1458453Read ↗

Analysis of in vivo somatic mutations at the APRT locus.Semantic proximity Read ↗

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