DNA sequence analysis of mutations induced by melphalan in the CHO aprt locus.

doi:10.1016/0165-4608(92)90326-4

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Article

DNA sequence analysis of mutations induced by melphalan in the CHO aprt locus.

Cancer genetics and cytogenetics - 1 Nov 1992

Austin M J, Han Y H, Povirk L F

Abstract excerpt

In previous work, we established that treatment with melphalan (L-phenylalanine mustard) produced a predominance of A.T-->T.A transversions in the Simian virus 40 (SV40)-based shuttle vector pZ189 during replication in human 293 cells. Mutations were induced with varying doses (4-12 microM) melph...

Topics

Adenine Phosphoribosyltransferase
Animals
Base Sequence
CHO Cells
Cell Survival
Chi-Square Distribution
Cricetinae
DNA Mutational Analysis
Melphalan
Molecular Sequence Data
Mutagenicity Tests
Mutagens
Mutation
Polymerase Chain Reaction

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