Article
Relative rates of insertion and deletion mutations in a microsatellite sequence in cultured cells.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999
Twerdi C D, Boyer J C, Farber R A
Abstract excerpt
A cell culture system has been used to determine the relative rates of insertions and deletions of integral numbers of dinucleotide repeats in a microsatellite sequence. A plasmid was constructed that contained 17 repeats of poly(dC-dA).poly(dG-dT) near the 5' end of a bacterial neomycin-resistance (neo) gene, such that the neo gene was translated in the (+1) reading frame. The plasmid was introduced into...
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