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Article

Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells.

Mutation research - 1 Jan 2000

Tindall K R, Stankowski L F

Abstract excerpt

AS52 cells are Chinese hamster ovary (CHO) cells that carry a single functional copy of the bacterial gpt gene and allow the isolation of 6-thioguanine-resistant (6TGr)mutants arising from mutation at the chromosally integrated gpt locus. The gpt locus in AS52 cells is extremely stable, giving rise to 6TGr mutants at frequencies comparable to the endogenous CHO hprt locus. In this study, we describe the spectrum...

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PMID: 2494446
DOI: 10.1016/0165-1110(89)90028-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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